A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

Cory M. Johannessen, Laura A. Johnson, Federica Piccioni, Aisha Townes, Dennie T. Frederick, Melanie K. Donahue, Rajiv Narayan, Keith T. Flaherty, Jennifer A. Wargo, David E. Root and Levi A. Garraway ()
Additional contact information
Cory M. Johannessen: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Laura A. Johnson: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Federica Piccioni: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Aisha Townes: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Dennie T. Frederick: Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
Melanie K. Donahue: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Rajiv Narayan: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Keith T. Flaherty: Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
Jennifer A. Wargo: Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
David E. Root: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
Levi A. Garraway: The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center

Nature, 2013, vol. 504, issue 7478, 138-142

Abstract: Expression of more than 15,500 genes individually in a melanoma cell line treated with RAF, MEK, ERK or combined RAF–MEK inhibitors reveals a cyclic-AMP-dependent melanocytic signalling network associated with drug resistance; this may represent a novel therapeutic target for melanoma treatment.

Date: 2013
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DOI: 10.1038/nature12688

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