Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

Qing Li (), Natacha Bohin, Tiffany Wen, Victor Ng, Jeffrey Magee, Shann-Ching Chen, Kevin Shannon and Sean J. Morrison ()
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Qing Li: University of Michigan
Natacha Bohin: University of Michigan
Tiffany Wen: University of Michigan
Victor Ng: University of Michigan
Jeffrey Magee: Howard Hughes Medical Institute, and Children's Research Institute, University of Texas Southwestern Medical Center
Shann-Ching Chen: St Jude Children’s Research Hospital
Kevin Shannon: University of California San Francisco
Sean J. Morrison: Howard Hughes Medical Institute, and Children's Research Institute, University of Texas Southwestern Medical Center

Nature, 2013, vol. 504, issue 7478, 143-147

Abstract: Oncogenic Nras in mouse haematopoietic stem cells can increase the probability of cell division in some cells and decrease it in others; this bimodal activity explains how this single pre-leukaemic mutation can increase proliferation without reducing competitiveness by clonally expanding the rapidly dividing cell population and also promoting long-term self-renewal of stem cells.

Date: 2013
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DOI: 10.1038/nature12830

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