Derivation of novel human ground state naive pluripotent stem cells

Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour, Yair S. Manor, Elad Chomsky, Dalit Ben-Yosef, Yael Kalma, Sergey Viukov, Itay Maza, Asaf Zviran, Yoach Rais, Zohar Shipony, Zohar Mukamel, Vladislav Krupalnik, Mirie Zerbib, Shay Geula, Inbal Caspi, Dan Schneir, Tamar Shwartz, Shlomit Gilad, Daniela Amann-Zalcenstein, Sima Benjamin, Ido Amit, Amos Tanay, Rada Massarwa (), Noa Novershtern () and Jacob H. Hanna ()
Additional contact information
Ohad Gafni: Weizmann Institute of Science, Rehovot 76100, Israel
Leehee Weinberger: Weizmann Institute of Science, Rehovot 76100, Israel
Abed AlFatah Mansour: Weizmann Institute of Science, Rehovot 76100, Israel
Yair S. Manor: Weizmann Institute of Science, Rehovot 76100, Israel
Elad Chomsky: Weizmann Institute of Science, Rehovot 76100, Israel
Dalit Ben-Yosef: Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center
Yael Kalma: Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center
Sergey Viukov: Weizmann Institute of Science, Rehovot 76100, Israel
Itay Maza: Weizmann Institute of Science, Rehovot 76100, Israel
Asaf Zviran: Weizmann Institute of Science, Rehovot 76100, Israel
Yoach Rais: Weizmann Institute of Science, Rehovot 76100, Israel
Zohar Shipony: Weizmann Institute of Science, Rehovot 76100, Israel
Zohar Mukamel: Weizmann Institute of Science, Rehovot 76100, Israel
Vladislav Krupalnik: Weizmann Institute of Science, Rehovot 76100, Israel
Mirie Zerbib: Weizmann Institute of Science, Rehovot 76100, Israel
Shay Geula: Weizmann Institute of Science, Rehovot 76100, Israel
Inbal Caspi: Weizmann Institute of Science, Rehovot 76100, Israel
Dan Schneir: Weizmann Institute of Science, Rehovot 76100, Israel
Tamar Shwartz: Wolfe PGD Stem Cell Lab, Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center
Shlomit Gilad: The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel
Daniela Amann-Zalcenstein: The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel
Sima Benjamin: The Israel National Center for Personalized Medicine (INCPM), Weizmann Institute of Science, Rehovot 76100, Israel
Ido Amit: Weizmann Institute of Science, Rehovot 76100, Israel
Amos Tanay: Weizmann Institute of Science, Rehovot 76100, Israel
Rada Massarwa: Weizmann Institute of Science, Rehovot 76100, Israel
Noa Novershtern: Weizmann Institute of Science, Rehovot 76100, Israel
Jacob H. Hanna: Weizmann Institute of Science, Rehovot 76100, Israel

Nature, 2013, vol. 504, issue 7479, 282-286

Abstract: It is known that human embryonic stem (ES) cells are more similar to mouse primed epiblast stem cells than to naive mouse ES cells; here culture conditions are determined that allow human ES and induced pluripotent stem cells to acquire a pluripotent state that retains growth characteristics highly similar to mouse naive ES cells, and competence in generating cross-species human-mouse embryonic chimaerism.

Date: 2013
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DOI: 10.1038/nature12745

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