High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Samuel A. Hasson, Lesley A. Kane, Koji Yamano, Chiu-Hui Huang, Danielle A. Sliter, Eugen Buehler, Chunxin Wang, Sabrina M. Heman-Ackah, Tara Hessa, Rajarshi Guha, Scott E. Martin and Richard J. Youle ()
Additional contact information
Samuel A. Hasson: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Lesley A. Kane: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Koji Yamano: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Chiu-Hui Huang: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Danielle A. Sliter: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Eugen Buehler: National Center for Advancing Translational Sciences, National Institutes of Health
Chunxin Wang: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Sabrina M. Heman-Ackah: NIH Center for Regenerative Medicine
Tara Hessa: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
Rajarshi Guha: National Center for Advancing Translational Sciences, National Institutes of Health
Scott E. Martin: National Center for Advancing Translational Sciences, National Institutes of Health
Richard J. Youle: Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health

Nature, 2013, vol. 504, issue 7479, 291-295

Abstract: Mitophagy is the elimination of damaged mitochondria by the autophagosome regulated by the ubiquitin ligase, parkin and the kinase PINK1; a genome-wide RNAi screen with high-content microscopy has identified new genes that have an upstream role in parkin translocation to the mitochondria.

Date: 2013
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DOI: 10.1038/nature12748

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