Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

Ioannis Manolaridis, Kiran Kulkarni, Roger B. Dodd, Satoshi Ogasawara, Ziguo Zhang, Ganka Bineva, Nicola O’Reilly, Sarah J. Hanrahan, Andrew J. Thompson, Nora Cronin, So Iwata and David Barford ()
Additional contact information
Ioannis Manolaridis: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Kiran Kulkarni: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Roger B. Dodd: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Satoshi Ogasawara: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Ziguo Zhang: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Ganka Bineva: Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Nicola O’Reilly: Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
Sarah J. Hanrahan: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Andrew J. Thompson: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Nora Cronin: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
So Iwata: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
David Barford: Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK

Nature, 2013, vol. 504, issue 7479, 301-305

Abstract: The crystal structure of an archaeal Rce1 protein has been determined; this protein represents a novel type of intramembrane protease, with a distinct architecture and catalytic site.

Date: 2013
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DOI: 10.1038/nature12754

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