Direct recording and molecular identification of the calcium channel of primary cilia

Paul G. DeCaen, Markus Delling, Thuy N. Vien and David E. Clapham ()
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Paul G. DeCaen: Howard Hughes Medical Institute, Children’s Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Markus Delling: Howard Hughes Medical Institute, Children’s Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Thuy N. Vien: Sackler School of Graduate Biomedical Sciences, Tufts University
David E. Clapham: Howard Hughes Medical Institute, Children’s Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2013, vol. 504, issue 7479, 315-318

Abstract: Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of these protrusions are unknown—this is one of two studies identifying the ion channels that densely populate primary cilia, with direct measurements revealing cilia as a unique, functionally independent calcium signalling compartment that modulates hedgehog signalling pathways.

Date: 2013
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DOI: 10.1038/nature12832

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