Primary cilia are specialized calcium signalling organelles

Markus Delling, Paul G. DeCaen, Julia F. Doerner, Sebastien Febvay and David E. Clapham ()
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Markus Delling: Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Paul G. DeCaen: Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Julia F. Doerner: Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
Sebastien Febvay: Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
David E. Clapham: Howard Hughes Medical Institute, Boston Children’s Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2013, vol. 504, issue 7479, 311-314

Abstract: Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of these protrusions are unknown—this is one of two studies identifying the ion channels that densely populate primary cilia, with direct measurements revealing cilia as a unique, functionally independent calcium signalling compartment that modulates hedgehog signalling pathways.

Date: 2013
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DOI: 10.1038/nature12833

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