Themis sets the signal threshold for positive and negative selection in T-cell development

Guo Fu, Javier Casas, Stephanie Rigaud, Vasily Rybakin, Florence Lambolez, Joanna Brzostek, John A. H. Hoerter, Wolfgang Paster, Oreste Acuto, Hilde Cheroutre, Karsten Sauer and Nicholas R. J. Gascoigne ()
Additional contact information
Guo Fu: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Javier Casas: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Stephanie Rigaud: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Vasily Rybakin: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Florence Lambolez: Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
Joanna Brzostek: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
John A. H. Hoerter: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Wolfgang Paster: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Oreste Acuto: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Hilde Cheroutre: Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California 92037, USA
Karsten Sauer: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nicholas R. J. Gascoigne: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA

Nature, 2013, vol. 504, issue 7480, 441-445

Abstract: This work shows that the Themis protein has a critical role in positive and negative thymocyte selection by dampening responses to low-affinity ligands but without affecting responses to high-affinity ligands, thus enabling positive selection of weakly self-reactive thymocytes.

Date: 2013
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DOI: 10.1038/nature12718

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