High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

Matthew D. Simon (), Stefan F. Pinter, Rui Fang, Kavitha Sarma, Michael Rutenberg-Schoenberg, Sarah K. Bowman, Barry A. Kesner, Verena K. Maier, Robert E. Kingston () and Jeannie T. Lee ()
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Matthew D. Simon: Massachusetts General Hospital, Harvard Medical School
Stefan F. Pinter: Massachusetts General Hospital, Harvard Medical School
Rui Fang: and Chemical Biology Institute, Yale University
Kavitha Sarma: Massachusetts General Hospital, Harvard Medical School
Michael Rutenberg-Schoenberg: and Chemical Biology Institute, Yale University
Sarah K. Bowman: Massachusetts General Hospital, Harvard Medical School
Barry A. Kesner: Massachusetts General Hospital, Harvard Medical School
Verena K. Maier: Massachusetts General Hospital, Harvard Medical School
Robert E. Kingston: Massachusetts General Hospital, Harvard Medical School
Jeannie T. Lee: Massachusetts General Hospital, Harvard Medical School

Nature, 2013, vol. 504, issue 7480, 465-469

Abstract: During mammalian X-chromosome inactivation, the Xist long noncoding RNA coats the future inactive X chromosome and recruits polycomb repressive complex 2 to a nucleation site, but how Xist spreads silencing across the entire X chromosome is unclear; here high-resolution maps of Xist binding sites across the X chromosome are generated and show that Xist does not spread across the inactive X chromosome uniformly but in two steps, initially targeting gene-rich islands before later spreading to intervening gene-poor domains.

Date: 2013
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DOI: 10.1038/nature12719

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