Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda (), Takaho A. Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N. Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M. Clarke, David L. Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, Jun Kikuchi, Kenya Honda, Koji Hase () and Hiroshi Ohno ()
Additional contact information
Yukihiro Furusawa: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Yuuki Obata: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Shinji Fukuda: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Takaho A. Endo: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Gaku Nakato: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Daisuke Takahashi: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Yumiko Nakanishi: Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan
Chikako Uetake: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Keiko Kato: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Tamotsu Kato: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Masumi Takahashi: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Noriko N. Fukuda: Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan
Shinnosuke Murakami: Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan
Eiji Miyauchi: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Shingo Hino: Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan
Koji Atarashi: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Satoshi Onawa: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Yumiko Fujimura: The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Trevor Lockett: Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia
Julie M. Clarke: Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia
David L. Topping: Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, South Australia 5000, Australia
Masaru Tomita: Institute for Advanced Biosciences, Keio University, Yamagata 997-0052, Japan
Shohei Hori: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Osamu Ohara: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Tatsuya Morita: Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan
Haruhiko Koseki: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Jun Kikuchi: Graduate School of Medical Life Science, Yokohama City University, Kanagawa 230-0045, Japan
Kenya Honda: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Koji Hase: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan
Hiroshi Ohno: RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Kanagawa 230-0045, Japan

Nature, 2013, vol. 504, issue 7480, 446-450

Abstract: The gut microbial metabolite butyrate is shown to induce the differentiation of colonic T regulatory cells in mice and to ameliorate the development of colitis; it also increases histone H3 acetylation at the Foxp3 promoter.

Date: 2013
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DOI: 10.1038/nature12721

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