The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality

Marko T. Boskovski, Shiaulou Yuan, Nis Borbye Pedersen, Christoffer Knak Goth, Svetlana Makova, Henrik Clausen, Martina Brueckner and Mustafa K. Khokha ()
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Marko T. Boskovski: Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Shiaulou Yuan: Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Nis Borbye Pedersen: Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, Building 24.6.30, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
Christoffer Knak Goth: Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, Building 24.6.30, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
Svetlana Makova: Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Henrik Clausen: Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, Building 24.6.30, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
Martina Brueckner: Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Mustafa K. Khokha: Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA

Nature, 2013, vol. 504, issue 7480, 456-459

Abstract: The O-glycosylation enzyme Galnt11 has an important role in heterotaxy, a disorder of left–right body patterning or laterality: Galnt11 modulates Notch signalling which alters cilia types at the embryonic left–right organizer, therefore determining laterality.

Date: 2013
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DOI: 10.1038/nature12723

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