Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

David J. Lloyd (), David J. St Jean, Robert J. M. Kurzeja, Robert C. Wahl, Klaus Michelsen, Rod Cupples, Michelle Chen, John Wu, Glenn Sivits, Joan Helmering, Renée Komorowski, Kate S. Ashton, Lewis D. Pennington, Christopher Fotsch, Mukta Vazir, Kui Chen, Samer Chmait, Jiandong Zhang, Longbin Liu, Mark H. Norman, Kristin L. Andrews, Michael D. Bartberger, Gwyneth Van, Elizabeth J. Galbreath, Steven L. Vonderfecht, Minghan Wang, Steven R. Jordan, Murielle M. Véniant and Clarence Hale ()
Additional contact information
David J. Lloyd: Amgen Inc., One Amgen Center Drive
David J. St Jean: Amgen Inc., One Amgen Center Drive
Robert J. M. Kurzeja: Amgen Inc., One Amgen Center Drive
Robert C. Wahl: Amgen Inc., One Amgen Center Drive
Klaus Michelsen: Amgen Inc., One Amgen Center Drive
Rod Cupples: Amgen Inc., One Amgen Center Drive
Michelle Chen: Amgen Inc., One Amgen Center Drive
John Wu: Amgen Inc., One Amgen Center Drive
Glenn Sivits: Amgen Inc., One Amgen Center Drive
Joan Helmering: Amgen Inc., One Amgen Center Drive
Renée Komorowski: Amgen Inc., One Amgen Center Drive
Kate S. Ashton: Amgen Inc., One Amgen Center Drive
Lewis D. Pennington: Amgen Inc., One Amgen Center Drive
Christopher Fotsch: Amgen Inc., One Amgen Center Drive
Mukta Vazir: Amgen Inc., One Amgen Center Drive
Kui Chen: Amgen Inc., One Amgen Center Drive
Samer Chmait: Amgen Inc., One Amgen Center Drive
Jiandong Zhang: Amgen Inc., One Amgen Center Drive
Longbin Liu: Amgen Inc., One Amgen Center Drive
Mark H. Norman: Amgen Inc., One Amgen Center Drive
Kristin L. Andrews: Amgen Inc., One Amgen Center Drive
Michael D. Bartberger: Amgen Inc., One Amgen Center Drive
Gwyneth Van: Amgen Inc., One Amgen Center Drive
Elizabeth J. Galbreath: Amgen Inc., One Amgen Center Drive
Steven L. Vonderfecht: Amgen Inc., One Amgen Center Drive
Minghan Wang: Amgen Inc., One Amgen Center Drive
Steven R. Jordan: Amgen Inc., One Amgen Center Drive
Murielle M. Véniant: Amgen Inc., One Amgen Center Drive
Clarence Hale: Amgen Inc., One Amgen Center Drive

Nature, 2013, vol. 504, issue 7480, 437-440

Abstract: Two small-molecule disruptors of the glucokinase–glucokinase-regulatory-protein complex, AMG-1694 and AMG-3969, are identified that decrease blood glucose levels in various models of hyperglycaemic rodents.

Date: 2013
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DOI: 10.1038/nature12724

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