Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Nicholas Arpaia, Clarissa Campbell, Xiying Fan, Stanislav Dikiy, Joris van der Veeken, Paul deRoos, Hui Liu, Justin R. Cross, Klaus Pfeffer, Paul J. Coffer and Alexander Y. Rudensky ()
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Nicholas Arpaia: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Clarissa Campbell: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Xiying Fan: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Stanislav Dikiy: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Joris van der Veeken: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Paul deRoos: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Hui Liu: Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan-Kettering Cancer Center
Justin R. Cross: Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan-Kettering Cancer Center
Klaus Pfeffer: Institute of Medical Microbiology and Hospital Hygiene, Heinrich-Heine-University Duesseldorf, Duesseldorf 40225, Germany
Paul J. Coffer: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center
Alexander Y. Rudensky: Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan-Kettering Cancer Center

Nature, 2013, vol. 504, issue 7480, 451-455

Abstract: In mice, provision of butyrate—a short-chain fatty acid produced by commensal microorganisms during starch fermentation—facilitates extrathymic generation and differentiation of Foxp3+ regulatory T cells, demonstrating that metabolic by-products are sensed by cells of the immune system and affect the balance between pro- and anti-inflammatory cells.

Date: 2013
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DOI: 10.1038/nature12726

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