Role of Tet1 in erasure of genomic imprinting

Shinpei Yamaguchi, Li Shen, Yuting Liu, Damian Sendler and Yi Zhang ()
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Shinpei Yamaguchi: Howard Hughes Medical Institute, Boston Children's Hospital
Li Shen: Howard Hughes Medical Institute, Boston Children's Hospital
Yuting Liu: Howard Hughes Medical Institute, Boston Children's Hospital
Damian Sendler: Howard Hughes Medical Institute, Boston Children's Hospital
Yi Zhang: Howard Hughes Medical Institute, Boston Children's Hospital

Nature, 2013, vol. 504, issue 7480, 460-464

Abstract: This study establishes an important role for the enzyme Tet1 in erasing genomic imprinting in vivo — mice with a knockout of paternal Tet1 give rise to progeny with imprinting defects and associated growth and development defects, which leads to early embryonic lethality; furthermore, analysis of the DNA methylation dynamics in reprogramming primordial germ cells (PGCs) suggests that Tet1 is required at a late stage of the reprogramming process, in the second wave of DNA demethylation in PGCs.

Date: 2013
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DOI: 10.1038/nature12805

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