Inconsistency in large pharmacogenomic studies

Benjamin Haibe-Kains (), Nehme El-Hachem, Nicolai Juul Birkbak, Andrew C. Jin, Andrew H. Beck, Hugo J. W. L. Aerts and John Quackenbush
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Benjamin Haibe-Kains: Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec, Canada
Nehme El-Hachem: Institut de Recherches Cliniques de Montréal, University of Montreal, Montreal, Quebec, Canada
Nicolai Juul Birkbak: Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark
Andrew C. Jin: Beth Israel Deaconess Medical Center and Harvard Medical School
Andrew H. Beck: Beth Israel Deaconess Medical Center and Harvard Medical School
Hugo J. W. L. Aerts: Dana-Farber Cancer Institute
John Quackenbush: Dana-Farber Cancer Institute

Nature, 2013, vol. 504, issue 7480, 389-393

Abstract: This Analysis compares two large-scale pharmacogenomic data sets that catalogued the sensitivity of a large number of cancer cell lines to approved and potential drugs, and finds that whereas the gene expression data are largely concordant between the two studies, the reported drug sensitivity measures and subsequently their association with genomic features are highly discordant.

Date: 2013
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DOI: 10.1038/nature12831

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