Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Sohini Mukherjee, Hui Zheng, Mehabaw G. Derebe, Keith M. Callenberg, Carrie L. Partch, Darcy Rollins, Daniel C. Propheter, Josep Rizo, Michael Grabe, Qiu-Xing Jiang () and Lora V. Hooper ()
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Sohini Mukherjee: The University of Texas Southwestern Medical Center
Hui Zheng: The University of Texas Southwestern Medical Center
Mehabaw G. Derebe: The University of Texas Southwestern Medical Center
Keith M. Callenberg: University of Pittsburgh, and Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology
Carrie L. Partch: University of California
Darcy Rollins: The University of Texas Southwestern Medical Center
Daniel C. Propheter: The University of Texas Southwestern Medical Center
Josep Rizo: The University of Texas Southwestern Medical Center
Michael Grabe: University of Pittsburgh, and Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology
Qiu-Xing Jiang: The University of Texas Southwestern Medical Center
Lora V. Hooper: The University of Texas Southwestern Medical Center

Nature, 2014, vol. 505, issue 7481, 103-107

Abstract: Secreted C-type lectins protect the intestinal epithelium from Gram-positive bacteria; this study shows that for the C-type lectin RegIIIα, bacterial killing occurs in a two-step process whereby the lectin first binds to bacterial peptidoglycans then oligomerizes on the bacterial membrane to form a permeabilizing pore.

Date: 2014
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DOI: 10.1038/nature12729

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