N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang, Zhike Lu, Adrian Gomez, Gary C. Hon, Yanan Yue, Dali Han, Ye Fu, Marc Parisien, Qing Dai, Guifang Jia, Bing Ren, Tao Pan and Chuan He ()
Additional contact information
Xiao Wang: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Zhike Lu: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Adrian Gomez: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Gary C. Hon: Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA
Yanan Yue: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Dali Han: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Ye Fu: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Marc Parisien: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Qing Dai: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Guifang Jia: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Bing Ren: Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA
Tao Pan: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Chuan He: The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA

Nature, 2014, vol. 505, issue 7481, 117-120

Abstract: The mRNAs of higher eukaryotes are extensively modified internally with N6-methyladenosine, but the specific functional role of this modification has been unclear; here this modification on mRNA is shown to be recognized by several proteins, the modification and its recognition serve to regulate the RNA’s lifetime.

Date: 2014
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DOI: 10.1038/nature12730

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