Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

Julien Courtin, Fabrice Chaudun, Robert R. Rozeske, Nikolaos Karalis, Cecilia Gonzalez-Campo, Hélène Wurtz, Azzedine Abdi, Jerome Baufreton, Thomas C. M. Bienvenu and Cyril Herry ()
Additional contact information
Julien Courtin: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Fabrice Chaudun: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Robert R. Rozeske: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Nikolaos Karalis: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Cecilia Gonzalez-Campo: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Hélène Wurtz: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Azzedine Abdi: University of Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France
Jerome Baufreton: University of Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France
Thomas C. M. Bienvenu: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
Cyril Herry: INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France

Nature, 2014, vol. 505, issue 7481, 92-96

Abstract: Single-unit recordings and optogenetic manipulations in mice undergoing auditory fear conditioning show that fear expression is related to the phasic inhibition of prefrontal cortex (PFC) parvalbumin interneurons; inhibition disinhibits PFC projection neurons and synchronizes their firing, leading to fear expression.

Date: 2014
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DOI: 10.1038/nature12755

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