Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform

Maria Enquist-Newman, Ann Marie E. Faust, Daniel D. Bravo, Christine Nicole S. Santos, Ryan M. Raisner, Arthur Hanel, Preethi Sarvabhowman, Chi Le, Drew D. Regitsky, Susan R. Cooper, Lars Peereboom, Alana Clark, Yessica Martinez, Joshua Goldsmith, Min Y. Cho, Paul D. Donohoue, Lily Luo, Brigit Lamberson, Pramila Tamrakar, Edward J. Kim, Jeffrey L. Villari, Avinash Gill, Shital A. Tripathi, Padma Karamchedu, Carlos J. Paredes, Vineet Rajgarhia, Hans Kristian Kotlar, Richard B. Bailey, Dennis J. Miller, Nicholas L. Ohler, Candace Swimmer () and Yasuo Yoshikuni ()
Additional contact information
Maria Enquist-Newman: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Ann Marie E. Faust: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Daniel D. Bravo: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Christine Nicole S. Santos: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Ryan M. Raisner: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Arthur Hanel: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Preethi Sarvabhowman: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Chi Le: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Drew D. Regitsky: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Susan R. Cooper: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Lars Peereboom: Michigan State University, 2527 Engineering Building, East Lansing, Michigan 48824-1226, USA
Alana Clark: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Yessica Martinez: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Joshua Goldsmith: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Min Y. Cho: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Paul D. Donohoue: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Lily Luo: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Brigit Lamberson: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Pramila Tamrakar: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Edward J. Kim: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Jeffrey L. Villari: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Avinash Gill: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Shital A. Tripathi: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Padma Karamchedu: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Carlos J. Paredes: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Vineet Rajgarhia: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Hans Kristian Kotlar: Statoil ASA, Statoil Research Centre, Arkitekt Ebbells vei 10, Rotvoll, 7005 Trondheim, Norway
Richard B. Bailey: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Dennis J. Miller: Michigan State University, 2527 Engineering Building, East Lansing, Michigan 48824-1226, USA
Nicholas L. Ohler: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Candace Swimmer: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA
Yasuo Yoshikuni: Bio Architecture Lab Inc., 604 Bancroft Way, Suite A, Berkeley, California 94710, USA

Nature, 2014, vol. 505, issue 7482, 239-243

Abstract: Saccharomyces cerevisiae bearing engineered alginate and mannitol catabolic pathways can ferment sugars from brown macroalgae to produce ethanol, potentially allowing the use of brown macroalgae as a viable feedstock for the production of biofuels and renewable chemicals.

Date: 2014
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DOI: 10.1038/nature12771

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