The effects of genetic variation on gene expression dynamics during development

Mirko Francesconi and Ben Lehner ()
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Mirko Francesconi: EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain
Ben Lehner: EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain

Nature, 2014, vol. 505, issue 7482, 208-211

Abstract: A comprehensive study into the effects of polymorphisms on gene expression dynamics during a 12-hour development period of Caenorhabditis elegans shows that both cis and trans expression quantitative trait loci (eQTLs) can increase and decrease gene expression, depending on the time point, and that trans eQTLs can act as modifiers of expression during a given period of development.

Date: 2014
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DOI: 10.1038/nature12772

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