Transcranial amelioration of inflammation and cell death after brain injury

Theodore L. Roth, Debasis Nayak, Tatjana Atanasijevic, Alan P. Koretsky, Lawrence L. Latour and Dorian B. McGavern ()
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Theodore L. Roth: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Debasis Nayak: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Tatjana Atanasijevic: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Alan P. Koretsky: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Lawrence L. Latour: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Dorian B. McGavern: National Institute of Neurological Disorders and Stroke, National Institutes of Health

Nature, 2014, vol. 505, issue 7482, 223-228

Abstract: Using long-term intravital photography to explore the cellular changes after compression-induced traumatic brain injury in a murine model, it is shown that parenchymal and meningeal inflammation as well as cell death can be modulated by topical treatment with purinergic receptor antagonists and glutathione.

Date: 2014
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DOI: 10.1038/nature12808

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