Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif

Yingying Guo, Liyong Dong, Xiaolin Qiu, Yishu Wang, Bailing Zhang, Hongnan Liu, You Yu, Yi Zang, Maojun Yang and Zhiwei Huang ()
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Yingying Guo: School of Life Science and Technology, Harbin Institute of Technology
Liyong Dong: School of Life Science and Technology, Harbin Institute of Technology
Xiaolin Qiu: School of Life Science and Technology, Harbin Institute of Technology
Yishu Wang: School of Life Science and Technology, Harbin Institute of Technology
Bailing Zhang: School of Life Science and Technology, Harbin Institute of Technology
Hongnan Liu: School of Life Science and Technology, Harbin Institute of Technology
You Yu: MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Yi Zang: School of Life Science and Technology, Harbin Institute of Technology
Maojun Yang: MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University
Zhiwei Huang: School of Life Science and Technology, Harbin Institute of Technology

Nature, 2014, vol. 505, issue 7482, 229-233

Abstract: This study provides a crystal structure of the Vif–CBF-β–CUL5–ELOB–ELOC complex, which shows that Vif mimics the action of SOCS2 to interact with CUL5 and ELOC.

Date: 2014
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DOI: 10.1038/nature12884

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