Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

Chi Nguyen, Robert W. Haushalter, D. John Lee, Phineus R. L. Markwick, Joel Bruegger, Grace Caldara-Festin, Kara Finzel, David R. Jackson, Fumihiro Ishikawa, Bing O’Dowd, J. Andrew McCammon, Stanley J. Opella, Shiou-Chuan Tsai () and Michael D. Burkart ()
Additional contact information
Chi Nguyen: Chemistry, and Pharmaceutical Sciences, University of California
Robert W. Haushalter: University of California, San Diego, La Jolla, California 92093, USA
D. John Lee: University of California, San Diego, La Jolla, California 92093, USA
Phineus R. L. Markwick: University of California, San Diego, La Jolla, California 92093, USA
Joel Bruegger: Chemistry, and Pharmaceutical Sciences, University of California
Grace Caldara-Festin: Chemistry, and Pharmaceutical Sciences, University of California
Kara Finzel: University of California, San Diego, La Jolla, California 92093, USA
David R. Jackson: Chemistry, and Pharmaceutical Sciences, University of California
Fumihiro Ishikawa: University of California, San Diego, La Jolla, California 92093, USA
Bing O’Dowd: University of California, San Diego, La Jolla, California 92093, USA
J. Andrew McCammon: University of California, San Diego, La Jolla, California 92093, USA
Stanley J. Opella: University of California, San Diego, La Jolla, California 92093, USA
Shiou-Chuan Tsai: Chemistry, and Pharmaceutical Sciences, University of California
Michael D. Burkart: University of California, San Diego, La Jolla, California 92093, USA

Nature, 2014, vol. 505, issue 7483, 427-431

Abstract: A highly specific chemical crosslinking method is used to trap a complex between an acyl carrier protein and a fatty acid dehydratase during fatty acid biosynthesis; subsequent X-ray crystallography, NMR spectroscopy and molecular dynamics simulations techniques enable the detailed study of this complex.

Date: 2014
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DOI: 10.1038/nature12810

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