Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period

Christina Whiteus, Catarina Freitas and Jaime Grutzendler ()
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Christina Whiteus: Yale University School of Medicine
Catarina Freitas: Yale University School of Medicine
Jaime Grutzendler: Yale University School of Medicine

Nature, 2014, vol. 505, issue 7483, 407-411

Abstract: In mice, chronic stimulation by repetitive sounds, whisker deflection, motor activity or seizures during a postnatal developmental critical period, leads to permanent reductions in brain microvascular density, an effect that impairs oxygen delivery to neurons but can be prevented by blocking nitric oxide signalling.

Date: 2014
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DOI: 10.1038/nature12821

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