The multilayered complexity of ceRNA crosstalk and competition

Yvonne Tay, John Rinn and Pier Paolo Pandolfi ()
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Yvonne Tay: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
John Rinn: Beth Israel Deaconess Medical Center
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2014, vol. 505, issue 7483, 344-352

Abstract: Abstract Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges — they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

Date: 2014
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DOI: 10.1038/nature12986

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