Structural basis of the alternating-access mechanism in a bile acid transporter

Xiaoming Zhou, Elena J. Levin, Yaping Pan, Jason G. McCoy, Ruchika Sharma, Brian Kloss, Renato Bruni, Matthias Quick () and Ming Zhou ()
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Xiaoming Zhou: Baylor College of Medicine
Elena J. Levin: Baylor College of Medicine
Yaping Pan: Baylor College of Medicine
Jason G. McCoy: Baylor College of Medicine
Ruchika Sharma: Columbia University
Brian Kloss: New York Consortium on Membrane Protein Structure
Renato Bruni: New York Consortium on Membrane Protein Structure
Matthias Quick: Columbia University
Ming Zhou: Baylor College of Medicine

Nature, 2014, vol. 505, issue 7484, 569-573

Abstract: Inhibitors of the bile acid transporter ASBT may be useful therapeutics for treating hypercholesterolaemia and type 2 diabetes; here, two X-ray crystal structures of an ASBT homologue from Yersinia frederiksenii are solved.

Date: 2014
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DOI: 10.1038/nature12811

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