Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

Daisuke Nakada (), Hideyuki Oguro, Boaz P. Levi, Nicole Ryan, Ayumi Kitano, Yusuke Saitoh, Makiko Takeichi, George R. Wendt and Sean J. Morrison ()
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Daisuke Nakada: Baylor College of Medicine
Hideyuki Oguro: Howard Hughes Medical Institute, and Children’s Research Institute, University of Texas Southwestern Medical Center
Boaz P. Levi: Life Sciences Institute, Center for Stem Cell Biology, University of Michigan
Nicole Ryan: Baylor College of Medicine
Ayumi Kitano: Baylor College of Medicine
Yusuke Saitoh: Baylor College of Medicine
Makiko Takeichi: Baylor College of Medicine
George R. Wendt: Life Sciences Institute, Center for Stem Cell Biology, University of Michigan
Sean J. Morrison: Howard Hughes Medical Institute, and Children’s Research Institute, University of Texas Southwestern Medical Center

Nature, 2014, vol. 505, issue 7484, 555-558

Abstract: Haematopoietic stem cells are found to be regulated differently in male and female mice — haematopoietic stem cells in females divide more frequently than in males in response to oestrogen and this difference depends on the ovaries but not the testes; using a genetic approach, it is shown that the effect is dependent on expression of oestrogen receptor-α (ERα) in stem cells.

Date: 2014
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DOI: 10.1038/nature12932

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