In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features

Yiliang Ding, Yin Tang, Chun Kit Kwok, Yu Zhang, Philip C. Bevilacqua () and Sarah M. Assmann ()
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Yiliang Ding: Pennsylvania State University, University Park
Yin Tang: Pennsylvania State University, University Park
Chun Kit Kwok: Pennsylvania State University, University Park
Yu Zhang: Bioinformatics and Genomics Graduate Program, Pennsylvania State University, University Park
Philip C. Bevilacqua: Pennsylvania State University, University Park
Sarah M. Assmann: Pennsylvania State University, University Park

Nature, 2014, vol. 505, issue 7485, 696-700

Abstract: RNA adopts vast and complicated secondary structures in the living cell; reported here is a new approach, structure-seq, that characterises RNA structure in vivo on a genome-wide scale at nucleotide resolution and should be applicable to any organism.

Date: 2014
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DOI: 10.1038/nature12756

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