Mutational and fitness landscapes of an RNA virus revealed through population sequencing

Ashley Acevedo, Leonid Brodsky and Raul Andino ()
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Ashley Acevedo: University of California
Leonid Brodsky: University of Haifa
Raul Andino: University of California

Nature, 2014, vol. 505, issue 7485, 686-690

Abstract: A new approach to accurately determine mutation frequencies with RNA virus populations called circular sequencing (CirSeq) has been developed; a study of the genetic composition of populations of poliovirus shows the fitness landscape for each nucleotide variant in an evolving RNA virus.

Date: 2014
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DOI: 10.1038/nature12861

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