Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

John W. Schoggins (), Donna A. MacDuff, Naoko Imanaka, Maria D. Gainey, Bimmi Shrestha, Jennifer L. Eitson, Katrina B. Mar, R. Blake Richardson, Alexander V. Ratushny, Vladimir Litvak, Rea Dabelic, Balaji Manicassamy, John D. Aitchison, Alan Aderem, Richard M. Elliott, Adolfo García-Sastre, Vincent Racaniello, Eric J. Snijder, Wayne M. Yokoyama, Michael S. Diamond, Herbert W. Virgin and Charles M. Rice ()
Additional contact information
John W. Schoggins: Laboratory of Virology and Infectious Disease, The Rockefeller University
Donna A. MacDuff: Washington University School of Medicine
Naoko Imanaka: Laboratory of Virology and Infectious Disease, The Rockefeller University
Maria D. Gainey: and Howard Hughes Medical Institute, Washington University School of Medicine
Bimmi Shrestha: Washington University School of Medicine
Jennifer L. Eitson: University of Texas Southwestern Medical Center
Katrina B. Mar: University of Texas Southwestern Medical Center
R. Blake Richardson: University of Texas Southwestern Medical Center
Alexander V. Ratushny: Seattle Biomedical Research Institute
Vladimir Litvak: Seattle Biomedical Research Institute
Rea Dabelic: Columbia University
Balaji Manicassamy: University of Chicago
John D. Aitchison: Seattle Biomedical Research Institute
Alan Aderem: Seattle Biomedical Research Institute
Richard M. Elliott: School of Biology, University of St Andrews, St Andrews, Scotland KY16 9ST, UK
Adolfo García-Sastre: Icahn School of Medicine at Mount Sinai
Vincent Racaniello: Columbia University
Eric J. Snijder: Leiden University Medical Center, Leiden 2300 RC, The Netherlands
Wayne M. Yokoyama: and Howard Hughes Medical Institute, Washington University School of Medicine
Michael S. Diamond: Washington University School of Medicine
Herbert W. Virgin: Washington University School of Medicine
Charles M. Rice: Laboratory of Virology and Infectious Disease, The Rockefeller University

Nature, 2014, vol. 505, issue 7485, 691-695

Abstract: The specificity of interferon effectors across an expanded range of viruses is studied, with results indicating that positive-sense single-stranded RNA viruses are more susceptible to interferon-stimulated gene activity than negative-sense RNA or DNA viruses; in addition, the DNA sensor cGAS is shown to have an unappreciated role in RNA virus inhibition.

Date: 2014
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DOI: 10.1038/nature12862

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