Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo

Silvi Rouskin, Meghan Zubradt, Stefan Washietl, Manolis Kellis and Jonathan S. Weissman ()
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Silvi Rouskin: California Institute of Quantitative Biology, Center for RNA Systems Biology, Howard Hughes Medical Institute, University of California
Meghan Zubradt: California Institute of Quantitative Biology, Center for RNA Systems Biology, Howard Hughes Medical Institute, University of California
Stefan Washietl: Massachusetts Institute of Technology
Manolis Kellis: Massachusetts Institute of Technology
Jonathan S. Weissman: California Institute of Quantitative Biology, Center for RNA Systems Biology, Howard Hughes Medical Institute, University of California

Nature, 2014, vol. 505, issue 7485, 701-705

Abstract: Understanding how RNA structure influences its function has been hampered by a lack of approaches that can accurately quantify RNA structure in vivo; here, RNA structure is revealed on a global scale and with nucleotide-level resolution, showing that there is less structure within cells than expected from in vitro and in silico analyses.

Date: 2014
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DOI: 10.1038/nature12894

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