Landscape and variation of RNA secondary structure across the human transcriptome

Yue Wan (), Kun Qu, Qiangfeng Cliff Zhang, Ryan A. Flynn, Ohad Manor, Zhengqing Ouyang, Jiajing Zhang, Robert C. Spitale, Michael P. Snyder, Eran Segal and Howard Y. Chang ()
Additional contact information
Yue Wan: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Kun Qu: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Qiangfeng Cliff Zhang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Ryan A. Flynn: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Ohad Manor: Weizmann Institute of Science, Rehovet 76100, Israel
Zhengqing Ouyang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Jiajing Zhang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Robert C. Spitale: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Michael P. Snyder: Stanford University School of Medicine
Eran Segal: Weizmann Institute of Science, Rehovet 76100, Israel
Howard Y. Chang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine

Nature, 2014, vol. 505, issue 7485, 706-709

Abstract: An RNA secondary structure (RSS) map of coding and noncoding RNA from a human family (two parents and their child) is produced; this reveals that approximately 15% of all transcribed single nucleotide variants (SNVs) alter local RNA structure, and these SNVs are depleted in certain locations, suggesting that particular RNA structures are important at those sites.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature12946 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:505:y:2014:i:7485:d:10.1038_nature12946

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12946

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().