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Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

Lijun Zhou, Jing Hang, Yulin Zhou, Ruixue Wan, Guifeng Lu, Ping Yin, Chuangye Yan and Yigong Shi ()
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Lijun Zhou: Ministry of Education Key Laboratory of Protein Science, Tsinghua University
Jing Hang: Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Yulin Zhou: Ministry of Education Key Laboratory of Protein Science, Tsinghua University
Ruixue Wan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University
Guifeng Lu: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University
Ping Yin: Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Chuangye Yan: Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Yigong Shi: Ministry of Education Key Laboratory of Protein Science, Tsinghua University

Nature, 2014, vol. 506, issue 7486, 116-120

Abstract: The crystal structure of the Lsm protein ring of the U6 small nuclear ribonucleoprotein (snRNP), with and without an RNA comprising the 3′ end of the U6 small nuclear RNA, is solved here; this structure provides insight into the function of U6 snRNP in precursor messenger RNA splicing.

Date: 2014
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DOI: 10.1038/nature12803

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