Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

Percy Tumbale, Jessica S. Williams, Matthew J. Schellenberg, Thomas A. Kunkel and R. Scott Williams ()
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Percy Tumbale: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
Jessica S. Williams: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
Matthew J. Schellenberg: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
Thomas A. Kunkel: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA
R. Scott Williams: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709, USA

Nature, 2014, vol. 506, issue 7486, 111-115

Abstract: This study shows that aprataxin, encoded by a gene mutated in the neurodegenerative disorder AOA1, can remove the 5′ AMP from RNA–DNA junctions; this RNA–DNA damage response promotes cell survival.

Date: 2014
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DOI: 10.1038/nature12824

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