Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

Marko Gogala, Thomas Becker, Birgitta Beatrix, Jean-Paul Armache, Clara Barrio-Garcia, Otto Berninghausen and Roland Beckmann ()
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Marko Gogala: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany
Thomas Becker: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany
Birgitta Beatrix: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany
Jean-Paul Armache: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany
Clara Barrio-Garcia: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany
Otto Berninghausen: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany
Roland Beckmann: Gene Center and Center for integrated Protein Science Munich, Feodor-Lynen-Strasse 25, University of Munich, 81377 Munich, Germany

Nature, 2014, vol. 506, issue 7486, 107-110

Abstract: Nascent secretory and membrane proteins are targeted to the Sec61 protein-conducting channel for translocation across or insertion into the endoplasmic reticulum membrane; here cryo-electron microscopy structures of eukaryotic ribosome–channel complexes show how this channel opens vertically during translocation of a secretory protein into the lumen of the endoplasmic reticulum and how it opens laterally during insertion of a transmembrane domain into the lipid bilayer.

Date: 2014
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DOI: 10.1038/nature12950

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