RNA viruses can hijack vertebrate microRNAs to suppress innate immunity

Derek W. Trobaugh, Christina L. Gardner, Chengqun Sun, Andrew D. Haddow, Eryu Wang, Elik Chapnik, Alexander Mildner, Scott C. Weaver, Kate D. Ryman and William B. Klimstra ()
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Derek W. Trobaugh: University of Pittsburgh
Christina L. Gardner: University of Pittsburgh
Chengqun Sun: University of Pittsburgh
Andrew D. Haddow: Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch
Eryu Wang: Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch
Elik Chapnik: Weizmann Institute of Science, Rehovot 7610001, Israel
Alexander Mildner: Weizmann Institute of Science, Rehovot 7610001, Israel
Scott C. Weaver: Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch
Kate D. Ryman: University of Pittsburgh
William B. Klimstra: University of Pittsburgh

Nature, 2014, vol. 506, issue 7487, 245-248

Abstract: Here it is proposed that RNA viruses can adapt to use the antiviral properties of microRNAs to limit viral replication and suppress innate immunity in particular cell types, and this restriction can lead to exacerbation of disease severity.

Date: 2014
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DOI: 10.1038/nature12869

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