Intranasal epidermal growth factor treatment rescues neonatal brain injury

Joseph Scafidi, Timothy R. Hammond, Susanna Scafidi, Jonathan Ritter, Beata Jablonska, Maria Roncal, Klara Szigeti-Buck, Daniel Coman, Yuegao Huang, Robert J. McCarter, Fahmeed Hyder, Tamas L. Horvath and Vittorio Gallo ()
Additional contact information
Joseph Scafidi: Center for Neuroscience Research, Children’s National Medical Center
Timothy R. Hammond: Center for Neuroscience Research, Children’s National Medical Center
Susanna Scafidi: Johns Hopkins University School of Medicine
Jonathan Ritter: Center for Neuroscience Research, Children’s National Medical Center
Beata Jablonska: Center for Neuroscience Research, Children’s National Medical Center
Maria Roncal: Center for Neuroscience Research, Children’s National Medical Center
Klara Szigeti-Buck: Yale University
Daniel Coman: MRRC, Yale University
Yuegao Huang: MRRC, Yale University
Robert J. McCarter: Center for Translational Science, Children’s National Medical Center, Washington DC 20010, USA
Fahmeed Hyder: MRRC, Yale University
Tamas L. Horvath: Yale University
Vittorio Gallo: Center for Neuroscience Research, Children’s National Medical Center

Nature, 2014, vol. 506, issue 7487, 230-234

Abstract: Diffuse white matter injury is common in very preterm infants; here, enhanced epidermal growth factor receptor signalling in oligodendrocyte precursor cells in a mouse model of such injury is shown to increase cellular and functional recovery.

Date: 2014
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DOI: 10.1038/nature12880

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