Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

Aruna Kode, John S. Manavalan, Ioanna Mosialou, Govind Bhagat, Chozha V. Rathinam, Na Luo, Hossein Khiabanian, Albert Lee, Vundavalli V. Murty, Richard Friedman, Andrea Brum, David Park, Naomi Galili, Siddhartha Mukherjee, Julie Teruya-Feldstein, Azra Raza, Raul Rabadan, Ellin Berman and Stavroula Kousteni ()
Additional contact information
Aruna Kode: College of Physicians & Surgeons, Columbia University
John S. Manavalan: College of Physicians & Surgeons, Columbia University
Ioanna Mosialou: College of Physicians & Surgeons, Columbia University
Govind Bhagat: College of Physicians & Surgeons, Columbia University
Chozha V. Rathinam: Columbia University
Na Luo: College of Physicians & Surgeons, Columbia University
Hossein Khiabanian: Columbia University
Albert Lee: Columbia University
Vundavalli V. Murty: Columbia University
Richard Friedman: Biomedical Informatics Shared Resource, College of Physicians & Surgeons, Columbia University
Andrea Brum: College of Physicians & Surgeons, Columbia University
David Park: Memorial Sloan-Kettering Cancer Center
Naomi Galili: Myelodysplastic Syndromes Center, Columbia University
Siddhartha Mukherjee: Departments of Medicine Hematology & Oncology Columbia University
Julie Teruya-Feldstein: Memorial Sloan-Kettering Cancer Center
Azra Raza: Myelodysplastic Syndromes Center, Columbia University
Raul Rabadan: Columbia University
Ellin Berman: Leukemia Service, Memorial Sloan-Kettering Cancer Center
Stavroula Kousteni: College of Physicians & Surgeons, Columbia University

Nature, 2014, vol. 506, issue 7487, 240-244

Abstract: A mouse model shows that osteoblast activating β-catenin mutations alone are sufficient to initiate the development of acute myeloid leukaemia acting through increased Notch signalling.

Date: 2014
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DOI: 10.1038/nature12883

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