C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells

Bruno Di Stefano, Jose Luis Sardina, Chris van Oevelen, Samuel Collombet, Eric M. Kallin, Guillermo P. Vicent, Jun Lu, Denis Thieffry, Miguel Beato and Thomas Graf ()
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Bruno Di Stefano: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain
Jose Luis Sardina: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain
Chris van Oevelen: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain
Samuel Collombet: Ecole Normale Supérieure, Institut de Biologie de l'ENS, 45 Rue d'Ulm, Paris F-75005, France
Eric M. Kallin: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain
Guillermo P. Vicent: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain
Jun Lu: Yale Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Denis Thieffry: Ecole Normale Supérieure, Institut de Biologie de l'ENS, 45 Rue d'Ulm, Paris F-75005, France
Miguel Beato: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain
Thomas Graf: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr Aiguader 88, 08003 Barcelona, Spain

Nature, 2014, vol. 506, issue 7487, 235-239

Abstract: A pulse of C/EBPα followed by overexpression of the transcription factors Oct4, Sox2, Klf4 and Myc leads to fast and very efficient reprogramming of B cell precursors to induced pluripotent stem cells; C/EBPα facilitates transient chromatin accessibility and accelerates expression of pluripotency genes through a mechanism that involves activation of the Tet2 enzyme.

Date: 2014
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DOI: 10.1038/nature12885

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