In situ identification of bipotent stem cells in the mammary gland

Anne C. Rios, Nai Yang Fu, Geoffrey J. Lindeman and Jane E. Visvader ()
Additional contact information
Anne C. Rios: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Nai Yang Fu: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Geoffrey J. Lindeman: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Jane E. Visvader: The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia

Nature, 2014, vol. 506, issue 7488, 322-327

Abstract: Abstract The mammary epithelium undergoes profound morphogenetic changes during development. Architecturally, it comprises two primary lineages, the inner luminal and outer myoepithelial cell layers. Two opposing concepts on the nature of mammary stem cells (MaSCs) in the postnatal gland have emerged. One model, based on classical transplantation assays, postulates that bipotent MaSCs have a key role in coordinating ductal epithelial expansion and maintenance in the adult gland, whereas the second model proposes that only unipotent MaSCs identified by lineage tracing contribute to these processes. Through clonal cell-fate mapping studies using a stochastic multicolour cre reporter combined with a new three-dimensional imaging strategy, we provide evidence for the existence of bipotent MaSCs as well as distinct long-lived progenitor cells. The cellular dynamics at different developmental stages support a model in which both stem and progenitor cells drive morphogenesis during puberty, whereas bipotent MaSCs coordinate ductal homeostasis and remodelling of the mouse adult gland.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature12948 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:506:y:2014:i:7488:d:10.1038_nature12948

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12948

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().