A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis

G. W. Liechti, E. Kuru, E. Hall, A. Kalinda, Y. V. Brun, M. VanNieuwenhze () and A. T. Maurelli ()
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G. W. Liechti: F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4799, USA
E. Kuru: Interdisciplinary Biochemistry Program, Indiana University
E. Hall: Indiana University
A. Kalinda: Indiana University
Y. V. Brun: Indiana University
M. VanNieuwenhze: Indiana University
A. T. Maurelli: F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814-4799, USA

Nature, 2014, vol. 506, issue 7489, 507-510

Abstract: Peptidoglycan is an essential structural component of the cell wall in the majority of bacteria, but the obligate intracellular human pathogen Chlamydia trachomatis was thought to be one of the few exceptions; here a click chemistry approach is used to label peptidoglycan in replicating C. trachomatis with novel d-amino acid dipeptide probes.

Date: 2014
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DOI: 10.1038/nature12892

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