Retraction Note: The NAD-dependent deacetylase SIRT2 is required for programmed necrosis

Nisha Narayan, In Hye Lee, Ronen Borenstein, Junhui Sun, Renee Wong, Guang Tong, Maria M. Fergusson, Jie Liu, Ilsa I. Rovira, Hwei-Ling Cheng, Guanghui Wang, Marjan Gucek, David Lombard, Fredrick W. Alt, Michael N. Sack, Elizabeth Murphy, Liu Cao and Toren Finkel

Nature, 2014, vol. 506, issue 7489, 516-516

Abstract: We retract this Article because some of the data, specifically the data reported in Fig. 2 demonstrating an in vitro requirement for Sirt2 in TNF-α-mediated necroptosis, appears to be irreproducible. We and others have confirmed that Sirt2 and RIP3interact, and we continue to believe that the absence of Sirt2 protects against ischaemic myocardial damage.

Date: 2014
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DOI: 10.1038/nature12897

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