Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

Tae-Hee Kim, Fugen Li, Isabel Ferreiro-Neira, Li-Lun Ho, Annouck Luyten, Kodandaramireddy Nalapareddy, Henry Long, Michael Verzi and Ramesh A. Shivdasani ()
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Tae-Hee Kim: Dana-Farber Cancer Institute
Fugen Li: Dana-Farber Cancer Institute
Isabel Ferreiro-Neira: Dana-Farber Cancer Institute
Li-Lun Ho: Dana-Farber Cancer Institute
Annouck Luyten: Dana-Farber Cancer Institute
Kodandaramireddy Nalapareddy: Dana-Farber Cancer Institute
Henry Long: Dana-Farber Cancer Institute
Michael Verzi: Dana-Farber Cancer Institute
Ramesh A. Shivdasani: Dana-Farber Cancer Institute

Nature, 2014, vol. 506, issue 7489, 511-515

Abstract: A study investigating the mechanisms underlying lateral inhibition and lineage plasticity in the mouse small intestine crypts in vivo finds that crypt cells maintain a permissive chromatin state upon which a transcription factor acts to determine lineage specification, and this is the basis of lateral inhibition.

Date: 2014
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DOI: 10.1038/nature12903

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