Stressful genetics in Crohn's disease
Arthur Kaser () and
Richard S. Blumberg ()
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Arthur Kaser: Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.
Richard S. Blumberg: Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature, 2014, vol. 506, issue 7489, 441-442
Abstract:
A common variant of the autophagy protein ATG16L1 is a risk factor for Crohn's disease. But the genetic alteration is revealed only when the protein is cleaved by the enzyme caspase 3 during cellular stress. See Article p.456
Date: 2014
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DOI: 10.1038/nature13060
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