Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

En-Zhi Shen, Chun-Qing Song, Yuan Lin, Wen-Hong Zhang, Pei-Fang Su, Wen-Yuan Liu, Pan Zhang, Jiejia Xu, Na Lin, Cheng Zhan, Xianhua Wang, Yu Shyr, Heping Cheng () and Meng-Qiu Dong ()
Additional contact information
En-Zhi Shen: College of Biological Sciences, China Agricultural University, Beijing 100094, China
Chun-Qing Song: College of Biological Sciences, China Agricultural University, Beijing 100094, China
Yuan Lin: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Wen-Hong Zhang: National Institute of Biological Sciences, Beijing, Beijing 102206, China
Pei-Fang Su: National Cheng Kung University, Tainan 70101, Taiwan
Wen-Yuan Liu: National Institute of Biological Sciences, Beijing, Beijing 102206, China
Pan Zhang: National Institute of Biological Sciences, Beijing, Beijing 102206, China
Jiejia Xu: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Na Lin: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Cheng Zhan: National Institute of Biological Sciences, Beijing, Beijing 102206, China
Xianhua Wang: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Yu Shyr: Vanderbilt Centre for Quantitative Sciences, Vanderbilt University
Heping Cheng: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Meng-Qiu Dong: National Institute of Biological Sciences, Beijing, Beijing 102206, China

Nature, 2014, vol. 508, issue 7494, 128-132

Abstract: In Caenorhabditis elegans, mitochondrial activity as measured by the frequency of the mitochondrial flash in young adult animals is a powerful predictor of lifespan across genetic, environmental and stochastic factors.

Date: 2014
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DOI: 10.1038/nature13012

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