Mouse liver repopulation with hepatocytes generated from human fibroblasts

Saiyong Zhu, Milad Rezvani, Jack Harbell, Aras N. Mattis, Alan R. Wolfe, Leslie Z. Benet, Holger Willenbring () and Sheng Ding ()
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Saiyong Zhu: Gladstone Institute of Cardiovascular Disease, 1650 Owens Street
Milad Rezvani: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
Jack Harbell: University of California San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
Aras N. Mattis: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
Alan R. Wolfe: University of California San Francisco, 533 Parnassus Avenue, San Francisco, California 94143, USA
Leslie Z. Benet: University of California San Francisco, 533 Parnassus Avenue, San Francisco, California 94143, USA
Holger Willenbring: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, 35 Medical Center Way
Sheng Ding: Gladstone Institute of Cardiovascular Disease, 1650 Owens Street

Nature, 2014, vol. 508, issue 7494, 93-97

Abstract: Human fibroblasts can be converted into hepatocytes capable of repopulating mouse livers by shortcutting reprogramming to pluripotency with factors promoting endoderm and hepatocyte differentiation.

Date: 2014
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DOI: 10.1038/nature13020

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