Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

Kıvanç Birsoy, Richard Possemato, Franziska K. Lorbeer, Erol C. Bayraktar, Prathapan Thiru, Burcu Yucel, Tim Wang, Walter W. Chen, Clary B. Clish and David M. Sabatini ()
Additional contact information
Kıvanç Birsoy: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Richard Possemato: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Franziska K. Lorbeer: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Erol C. Bayraktar: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Prathapan Thiru: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Burcu Yucel: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Tim Wang: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Walter W. Chen: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Clary B. Clish: Broad Institute of Harvard and MIT, Seven Cambridge Center
David M. Sabatini: Whitehead Institute for Biomedical Research, Nine Cambridge Center

Nature, 2014, vol. 508, issue 7494, 108-112

Abstract: New apparatus is used to maintain proliferating cancer cells in low-glucose conditions, demonstrating that mitochondrial oxidative phosphorylation (OXPHOS) is essential for optimal proliferation in these conditions; the most sensitive cell lines are defective in OXPHOS upregulation and may therefore be sensitive to current antidiabetic drugs that inhibit OXPHOS.

Date: 2014
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DOI: 10.1038/nature13110

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