Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia

Yilong Li, Claire Schwab, Sarra L. Ryan, Elli Papaemmanuil, Hazel M. Robinson, Patricia Jacobs, Anthony V. Moorman, Sara Dyer, Julian Borrow, Mike Griffiths, Nyla A. Heerema, Andrew J. Carroll, Polly Talley, Nick Bown, Nick Telford, Fiona M. Ross, Lorraine Gaunt, Richard J. Q. McNally, Bryan D. Young, Paul Sinclair, Vikki Rand, Manuel R. Teixeira, Olivia Joseph, Ben Robinson, Mark Maddison, Nicole Dastugue, Peter Vandenberghe, Claudia Haferlach, Philip J. Stephens, Jiqiu Cheng, Peter Van Loo, Michael R. Stratton, Peter J. Campbell () and Christine J. Harrison ()
Additional contact information
Yilong Li: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Claire Schwab: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Sarra L. Ryan: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Elli Papaemmanuil: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Hazel M. Robinson: West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
Patricia Jacobs: Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury SP2 8BJ, UK
Anthony V. Moorman: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Sara Dyer: West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
Julian Borrow: West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
Mike Griffiths: West Midlands Regional Genetics Laboratory, Birmingham Women’s NHS Foundation Trust, Birmingham B15 2TG, UK
Nyla A. Heerema: The Ohio State University
Andrew J. Carroll: University of Alabama at Birmingham
Polly Talley: Sheffield Diagnostic Genetics Service, Sheffield Children’s NHS Foundation Trust, Sheffield S10 2TH, UK
Nick Bown: Cytogenetics Laboratory, Northern Genetics Service, Newcastle upon Tyne NE7 7DN, UK
Nick Telford: Oncology Cytogenetics, The Christie NHS Foundation Trust, Manchester M20 4BX, UK
Fiona M. Ross: Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury SP2 8BJ, UK
Lorraine Gaunt: Regional Cytogenetics Unit, Genetic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Saint Mary’s Hospital, Manchester M13 9WL, UK
Richard J. Q. McNally: Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
Bryan D. Young: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Paul Sinclair: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Vikki Rand: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
Manuel R. Teixeira: Portuguese Oncology Institute, Porto University, 4200-072 Porto, Portugal
Olivia Joseph: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Ben Robinson: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Mark Maddison: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Nicole Dastugue: Laboratoire d’Hématologie, Génétique des Hémopathies, Hôpital Purpan, 31059 Toulouse, France
Peter Vandenberghe: Center for Human Genetics, University Hospital Leuven, 3000 Leuven, Belgium
Claudia Haferlach: MLL Munich Leukemia Laboratory, Munich 81377, Germany
Philip J. Stephens: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Jiqiu Cheng: Center for Human Genetics, University Hospital Leuven, 3000 Leuven, Belgium
Peter Van Loo: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Michael R. Stratton: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Peter J. Campbell: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Christine J. Harrison: Leukaemia Research Cytogenetics Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Nature, 2014, vol. 508, issue 7494, 98-102

Abstract: A rare constitutional translocation between chromosomes 15 and 21 predisposes to catastrophic chromosomal damage followed by amplification of megabase regions, causing a specific subtype of acute lymphoblastic leukaemia.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature13115 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13115

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13115

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().