XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Xi Chen, Dimitrios Iliopoulos, Qing Zhang, Qianzi Tang, Matthew B. Greenblatt, Maria Hatziapostolou, Elgene Lim, Wai Leong Tam, Min Ni, Yiwen Chen, Junhua Mai, Haifa Shen, Dorothy Z. Hu, Stanley Adoro, Bella Hu, Minkyung Song, Chen Tan, Melissa D. Landis, Mauro Ferrari, Sandra J. Shin, Myles Brown, Jenny C. Chang, X. Shirley Liu and Laurie H. Glimcher ()
Additional contact information
Xi Chen: Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
Dimitrios Iliopoulos: Center for Systems Biomedicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Qing Zhang: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Qianzi Tang: School of Life Science and Technology, Tongji University
Matthew B. Greenblatt: Brigham and Women's Hospital
Maria Hatziapostolou: Center for Systems Biomedicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
Elgene Lim: Harvard Medical School
Wai Leong Tam: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Min Ni: Harvard Medical School
Yiwen Chen: Dana-Farber Cancer Institute and Harvard School of Public Health
Junhua Mai: Houston Methodist Research Institute
Haifa Shen: Houston Methodist Research Institute
Dorothy Z. Hu: Endocrine Unit, Massachusetts General Hospital
Stanley Adoro: Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
Bella Hu: Children’s Hospital Boston
Minkyung Song: Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
Chen Tan: Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
Melissa D. Landis: Houston Methodist Cancer Center
Mauro Ferrari: Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
Sandra J. Shin: Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
Myles Brown: Harvard Medical School
Jenny C. Chang: Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
X. Shirley Liu: Dana-Farber Cancer Institute and Harvard School of Public Health
Laurie H. Glimcher: Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue

Nature, 2014, vol. 508, issue 7494, 103-107

Abstract: This study finds that triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 promotes tumour formation of TNBC cell lines by interacting with and regulating HIF1α.

Date: 2014
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DOI: 10.1038/nature13119

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