Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl and Edward J. Gunther ()
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Allison S. Cleary: Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine
Travis L. Leonard: Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine
Shelley A. Gestl: Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine
Edward J. Gunther: Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine

Nature, 2014, vol. 508, issue 7494, 113-117

Abstract: In a mouse model of tumours initiated by Wnt signalling in which a proportion of tumours are biclonal, that is, composed of basal and luminal clones with distinct genetic alterations, these clones are shown to cooperate to maintain tumour growth in a Wnt-dependent manner.

Date: 2014
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DOI: 10.1038/nature13187

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